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1

Thermodynamics of nucleic acids and their interactions with ligands

Lane, Andrew N., Jenkins, Terence C.

Journal:

Quarterly Reviews of Biophysics

Year:

2000

Language:

english

File:

PDF, 724 KB

english, 2000

2

Stabilization of DNA triple helices by a series of mono- and disubstituted amidoanthraquinones

Melanie D. Keppler, Martin A. Read, Philip J. Perry, John O. Trent, Terence C. Jenkins, Anthony P. Reszka, Stephen Neidle, Keith R. Fox

Journal:

Year:

1999

Language:

english

File:

PDF, 937 KB

english, 1999

3

Design, Synthesis, and Evaluation of Novel Biarylpyrimidines: A New Class of Ligand for Unusual Nucleic Acid Structures

Wheelhouse, Richard T., Jennings, Sharon A., Phillips, Victoria A., Pletsas, Dimitrios, Murphy, Peter M., Garbett, Nichola C., Chaires, Jonathan B., Jenkins, Terence C.

Journal:

Journal of Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 376 KB

english, 2006

4

Inhibition of Bacteriophage T7 RNA Polymerase in Vitro Transcription by DNA-Binding Pyrrolo[2,1- c ][1,4]benzodiazepines †

Puvvada, Madhu S., Forrow, Stephen A., Hartley, John A., Stephenson, Pauline, Gibson, Ian, Jenkins, Terence C., Thurston, David E.

Journal:

Year:

1997

Language:

english

File:

PDF, 334 KB

english, 1997

5

A Molecular Anchor for Stabilizing Triple-Helical DNA

Keith R. Fox, Paolo Polucci, Terence C. Jenkins and Stephen Neidle

Journal:

Proceedings of the National Academy of Sciences

Year:

1995

Language:

english

File:

PDF, 1.06 MB

english, 1995

6

ChemInform Abstract: Synthesis of a Novel C2/C2′-exo Unsaturated Pyrrolobenzodiazepine Cross-Linking Agent with Remarkable DNA Binding Affinity and Cytotoxicity.

Stephen J. Gregson, Philip W. Howard, Terence C. Jenkins, Lloyd R. Kelland, David E. Thurston

Journal:

Year:

1999

File:

PDF, 40 KB

1999

7

ChemInform Abstract: Targeting Multi-Stranded DNA Structures

Terence C. Jenkins

Journal:

Year:

2000

File:

PDF, 24 KB

2000

8

ChemInform Abstract: Effect of C2/C3-endo Unsaturation on the Cytotoxicity and DNA-Binding Reactivity of Pyrrolo[2,1-c][1,4]benzodiazepines.

Stephen J. Gregson, Philip W. Howard, Simona Barcella, Anthonia Nakamya, Terence C. Jenkins, Lloyd R. Kelland, David E. Thurston

Journal:

Year:

2000

File:

PDF, 35 KB

2000

9

ChemInform Abstract: Effect of C2-exo Unsaturation on the Cytotoxicity and DNA-Binding Reactivity of Pyrrolo[2,1-c][1,4]benzodiazepines.

Stephen J. Gregson, Philip W. Howard, Kathryn E. Corcoran, Simona Barcella, Maqsood M. Yasin, Abigail A. Hurst, Terence C. Jenkins, Lloyd R. Kelland, David E. Thurston

Journal:

Year:

2000

File:

PDF, 35 KB

2000

10

ChemInform Abstract: Design, Synthesis, and Evaluation of a Novel Pyrrolobenzodiazepine DNA-Interactive Agent with Highly Efficient Cross-Linking Ability and Potent Cytotoxicity.

Stephen J. Gregson, Philip W. Howard, John A. Hartley, Natalie A. Brooks, Lesley J. Adams, Terence C. Jenkins, Lloyd R. Kelland, David E. Thurston

Journal:

Year:

2001

File:

PDF, 34 KB

2001

11

ChemInform Abstract: Synthesis of the First Example of a C2-C3/C2′-C3′-endo Unsaturated Pyrrolo[2,1-c][1,4]benzodiazepine Dimer.

Stephen J. Gregson, Philip W. Howard, Kathryn E. Corcoran, Terence C. Jenkins, Lloyd R. Kelland, David E. Thurston

Journal:

Year:

2002

File:

PDF, 29 KB

2002

12

The Synthesis and Biological Activity of C2-Fluorinated Pyrrolo[2,1-c][1,4]benzodiazepines.

Ian A. O'Neil, Stephen Thompson, S. Barret Kalindjian, Terence C. Jenkins

Journal:

Year:

2004

File:

PDF, 125 KB

2004

13

Synthesis and Biological Evaluation of Pyrrolo[2,1-c][1,4]benzodiazepine (PBD) C8 Cyclic Amine Conjugates.

Luke A. Masterson, Stephen J. Croker, Terence C. Jenkins, Philip W. Howard, David E. Thurston

Journal:

Year:

2004

File:

PDF, 128 KB

2004

14

Identification of butyryl derivatives of cyclic nucleotides by positive ion fast atom bombardment mass spectrometry and mass-analysed ion kinetic energy spectrometry

Russell P. Newton, Terence J. Walton, Salem A. Basaif, Andrea M. Jenkins, A. Gareth Brenton, Dipankar Ghosh, Frank M. Harris

Journal:

Journal of Mass Spectrometry

Year:

1989

Language:

english

File:

PDF, 887 KB

english, 1989

15

Demonstration of two non-radiative pathways in the decay of luminescent complexes of ruthenium(II) in a variety of solvents

Stephen R. Allsopp, Alna Cox, Stephen H. Jenkins, Terence J. Kemp, Stephen M. Tunstall

Journal:

Chemical Physics Letters

Year:

1976

Language:

english

File:

PDF, 245 KB

english, 1976

16

The phosphate-group of dna as a potential target for RSU-1069, a nitroimidazole-aziridine radiosensitizer

Andrew R.J. Silver, Peter O'Neill, Terence C. Jenkins, Shona S. McNeil

Journal:

International Journal of Radiation Oncology*Biology*Physics

Year:

1986

Language:

english

File:

PDF, 391 KB

english, 1986

17

Synthesis of a novel C2-aryl pyrrolo[2,1-c][1,4]benzodiazepine-5,11-dione library: Effect of C2-aryl substitution on cytotoxicity and non-covalent DNA binding

Dyeison Antonow, Terence C. Jenkins, Philip W. Howard, David E. Thurston

Journal:

Bioorganic & Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 348 KB

english, 2007

18

Synthesis and biological evaluation of pyrrolo[2,1-c][1,4]benzodiazepine (PBD) C8 cyclic amine conjugates

Luke A. Masterson, Stephen J. Croker, Terence C. Jenkins, Philip W. Howard, David E. Thurston

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 173 KB

english, 2004

19

Fluorescent 7-diethylaminocoumarin pyrrolobenzodiazepine conjugates: Synthesis, DNA interaction, cytotoxicity and differential cellular localization

Geoffrey Wells, Marie Suggitt, Marissa Coffils, Mirza A.H. Baig, Philip W. Howard, Paul M. Loadman, John A. Hartley, Terence C. Jenkins, David E. Thurston

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 212 KB

english, 2008

20

Novel C8-linked pyrrolobenzodiazepine (PBD)–heterocycle conjugates that recognize DNA sequences containing an inverted CCAAT box

Federico Brucoli, Rachel M. Hawkins, Colin H. James, Geoff Wells, Terence C. Jenkins, Tom Ellis, John A. Hartley, Philip W. Howard, David E. Thurston

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 488 KB

english, 2011

21

Polar, functionalized guanine-O6 derivatives resistant to repair by O6-alkylguanine–DNA alkyltransferase: implications for the design of DNA-modifying drugs

Dimitrios Pletsas, Richard T. Wheelhouse, Vassiliki Pletsa, Anna Nicolaou, Terence C. Jenkins, Michael C. Bibby, Soterios A. Kyrtopoulos

Journal:

European Journal of Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 419 KB

english, 2006

22

The synthesis and biological activity of C2-fluorinated pyrrolo[2,1-c][1,4]benzodiazepines

Ian A. O'Neil, Stephen Thompson, S.Barret Kalindjian, Terence C. Jenkins

Journal:

Tetrahedron Letters

Year:

2003

Language:

english

File:

PDF, 135 KB

english, 2003

23

An unexpected ring contraction of two nitroaryl pro-drugs: conversion of N-(nitroaryl)-3-chloropiperidine derivatives into N-(nitroaryl)-2-chloromethylpyrrolidines

Philip J. Burke, Lai Chun Wong, William Clegg, Ross W. Harrington, Terence C. Jenkins, Richard J. Knox, Ian T. Meikle, Stephen P. Stanforth

Journal:

Tetrahedron Letters

Year:

2010

Language:

english

File:

PDF, 296 KB

english, 2010

24

Time-division multiplex technique for producing concentration profiles in flow analysis

Xue D Wang, Terence J Cardwell, Robert W Cattrall, Robert P Dyson, Graeme E Jenkins

Journal:

Analytica Chimica Acta

Year:

1998

Language:

english

File:

PDF, 193 KB

english, 1998

25

Oxidations with acylnitroxyls

S. Altaf Hussain, Terence C. Jenkins, M. John Perkins

Journal:

Tetrahedron Letters

Year:

1977

Language:

english

File:

PDF, 184 KB

english, 1977

26

Some magnetic resonance parameters for acyl nitroxides: A comment on nitroxide configuration.

Terence C. Jenkins, M.John Perkins, Bulent Terem

Journal:

Tetrahedron Letters

Year:

1978

Language:

english

File:

PDF, 169 KB

english, 1978

27

Effect of C2/C3-endo unsaturation on the cytotoxicity and dna-binding reactivity of pyrrolo[2,1-c][1,4]benzodiazepines

Stephen J. Gregson, Philip W. Howard, Simona Barcella, Anthonia Nakamya, Terence C. Jenkins, Lloyd R. Kelland, David E. Thurston

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2000

Language:

english

File:

PDF, 165 KB

english, 2000

28

Effect of C2-exo unsaturation on the cytotoxicity and DNA-binding reactivity of pyrrolo[2,1-c][1,4]benzodiazepines

Stephen J. Gregson, Philip W. Howard, Kathryn E. Corcoran, Simona Barcella, Maqsood M. Yasin, Abigail A. Hurst, Terence C. Jenkins, Lloyd R. Kelland, David E. Thurston

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2000

Language:

english

File:

PDF, 158 KB

english, 2000

29

Synthesis of the first example of a c2-C3/C2′-C3′-endo unsaturated pyrrolo[2,1-c][1,4]benzodiazepine dimer

Stephen J Gregson, Philip W Howard, Kathryn E Corcoran, Terence C Jenkins, Lloyd R Kelland, David E Thurston

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 130 KB

english, 2001

30

Molecular Modelling and Cytotoxicity of Substituted Anthraquinones as Inhibitors of Human Telomerase

Donald Cairns, Evangelia Michalitsi, Terence C Jenkins, Simon P Mackay

Journal:

Bioorganic & Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 157 KB

english, 2002

31

Genotoxicity studies on DNA-interactive telomerase inhibitors with application as anti-cancer agents

Dean J. Harrington, Eduardo Cemeli, Joanna Carder, Jamie Fearnley, Sian Estdale, Philip J. Perry, Terence C. Jenkins, Diana Anderson

Journal:

Teratogenesis, Carcinogenesis, and Mutagenesis

Year:

2003

Language:

english

File:

PDF, 170 KB

english, 2003

32

Characterization of theLmo4gene encoding a LIM-only protein: genomic organization and comparative chromosomal mapping

Eric Tse, Gerald Grutz, Andrea A. Garner, Yvonne Ramsey, Nigel P. Carter, Neal Copeland, Debra J. Gilbert, Nancy A. Jenkins, Alan Agulnick, Alan Forster, Terence H. Rabbitts

Journal:

Mammalian Genome

Year:

1999

Language:

english

File:

PDF, 561 KB

english, 1999

33

Preparation and Chemical and Biological Studies of the Novel Complex

Wagner M. Teles, Flávia C. Machado, Carlos A. Montanari, Carlos A. L. Filgueiras, Terence C. Jenkins

Journal:

Transition Metal Chemistry

Year:

2005

Language:

english

File:

PDF, 214 KB

english, 2005

34

Preliminary pharmacokinetic and bioanalytical studies of SJG-136 (NSC 694501), a sequence-selective pyrrolobenzodiazepine dimer DNA-cross-linking agent

Gary P. Wilkinson, James P. Taylor, Steve Shnyder, Patricia Cooper, Phil W. Howard, David E. Thurston, Terence C. Jenkins, Paul M. Loadman

Journal:

Investigational New Drugs

Year:

2004

Language:

english

File:

PDF, 165 KB

english, 2004

35

Novel Acridine-Triazenes as Prototype Combilexins: Synthesis, DNA Binding, and Biological Activity

McConnaughie, Adrian W., Jenkins, Terence C.

Journal:

Journal of Medicinal Chemistry

Year:

1995

Language:

english

File:

PDF, 2.11 MB

english, 1995

36

Human Telomerase Inhibition by Regioisomeric Disubstituted Amidoanthracene-9,10-diones

Perry, Philip J., Reszka, Anthony P., Wood, Alexis A., Read, Martin A., Gowan, Sharon M., Dosanjh, Harvinder S., Trent, John O., Jenkins, Terence C., Kelland, Lloyd R., Neidle, Stephen

Journal:

Journal of Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 216 KB

english, 1998

37

ChemInform Abstract: The Synthesis of 2-Nitroaryl-1,2,3,4-tetrahydroisoquinolines, Nitro-Substituted 5,6-Dihydrobenzimidazo[2,1-a]isoquinoline N-Oxides and Related Heterocycles as Potential Bioreducible Substrates for the Enzymes NAD(P)H: Quinone Oxidoreductase 1 and E. coli Nitroreductase.

Philip J. Burke, Lai Chun Wong, Terence C. Jenkins, Richard J. Knox, Stephen P. Stanforth

Journal:

Year:

2012

File:

PDF, 33 KB

2012

38

Genotoxic effects of 3-amino-1,2,4-benzotriazine-1, 4-dioxide (SR 4233) and nitrogen mustard-N-oxide (nitromin) in Walker carcinoma cells under aerobic and hypoxic conditions

Alan Cabill, Terence C. Jenkins, Pamela Pickering, Ian N.H. White

Journal:

Chemico-Biological Interactions

Year:

1995

Language:

english

File:

PDF, 804 KB

english, 1995

39

The synthesis of 2-nitroaryl-1,2,3,4-tetrahydroisoquinolines, nitro-substituted 5,6-dihydrobenzimidazo[2,1-a]isoquinoline N-oxides and related heterocycles as potential bioreducible substrates for the enzymes NAD(P)H: quinone oxidoreductase 1 and E. coli nitroreductase

Philip J. Burke, Lai Chun Wong, Terence C. Jenkins, Richard J. Knox, Stephen P. Stanforth

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 295 KB

english, 2011

40

AT selectivity and DNA minor groove binding: modelling, NMR and structural studies of the interactions of propamidine and pentamidine with d(CGCGAATTCGCG)2

Terence C Jenkins, Andrew N Lane

Journal:

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression

Year:

1997

Language:

english

File:

PDF, 556 KB

english, 1997

41

Hydration and solution structure of d(CGCAAATTTGCG)2 and its complex with propamidine from NMR and molecular modelling

Andrew N Lane, Terence C Jenkins, Thomas A Frenkiel

Journal:

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression

Year:

1997

Language:

english

File:

PDF, 512 KB

english, 1997

42

NMR and molecular modeling studies of the interaction of berenil and pentamidine with d(CGCAAATTTGCG)2

Terence C. JENKINS, Andrew N. LANE, Stephen NEIDLE, David G. BROWN

Journal:

Year:

1993

Language:

english

File:

PDF, 1.04 MB

english, 1993

43

Crystal Structure of γ-Oxapentamidine Complexed with d(CGCGAATTCGCG)2 : The Effects of Drug Structural Change on DNA Minor-Groove Recognition

Christine M. Nunn, Terence C. Jenkins, Stephen Neidle

Journal:

Year:

1994

Language:

english

File:

PDF, 837 KB

english, 1994

44

Interaction of Minor-Groove-Binding Diamidine Ligands with an Asymmetric DNA Duplex : NMR and Molecular Modelling Studies

Maria R. Conte, Terence C. Jenkins, Andrew N. Lane

Journal:

Year:

1995

Language:

english

File:

PDF, 1.43 MB

english, 1995

45

A Novel Series of DNA Triple Helix-Binding Ligands

Keith R. Fox, David E. Thurston, Terence C. Jenkins, Athanasia Varvaresou, Andrew Tsotinis, Theodora Siatra-Papastaikoudi

Journal:

Biochemical and Biophysical Research Communications

Year:

1996

Language:

english

File:

PDF, 146 KB

english, 1996

46

Specific binding of hoechst 33258 to the d(CGCAAATTTGCG)2 duplex: calorimetric and spectroscopic studies

Ihtshamul Haq, John E Ladbury, Babur Z Chowdhry, Terence C Jenkins, Jonathan B Chaires

Journal:

Journal of Molecular Biology

Year:

1997

Language:

english

File:

PDF, 346 KB

english, 1997

47

Induction of DNA strand breaks by reduced nitroimidazoles: Implications for DNA base damage

Andrew R.J. Silver, Shona S. Mcneil, Peter O'Neill, Terence C. Jenkins, Israr Ahmed

Journal:

Biochemical Pharmacology

Year:

1986

Language:

english

File:

PDF, 904 KB

english, 1986

48

Induction of DNA strand breaks by RSU-1069, a nitroimidazole-aziridine radiosensitizer: Role of binding of both unreduced and radiation-reduced forms to DNA, in vitro

Andrew R.J. Silver, Peter O'Neill, Terence C. Jenkins

Journal:

Biochemical Pharmacology

Year:

1985

Language:

english

File:

PDF, 802 KB

english, 1985

49

Effects of substituted 2-nitroimidazoles and related compounds on unscheduled DNA synthesis in rat hepatocytes and in non-transformed (BL8) and transformed (JB1) rat liver epithelial derived cell lines

Mohammad Suzangar, Ian N.H. White, Terence C. Jenkins, Thomas A. Connors

Journal:

Biochemical Pharmacology

Year:

1987

Language:

english

File:

PDF, 618 KB

english, 1987

50

Induction of DNA crosslinks in vitro upon reduction of the nitroimidazole-aziridines RSU-1069 and RSU-1131

Peter O'Neill, Shona S. McNeil, Terence C. Jenkins

Journal:

Biochemical Pharmacology

Year:

1987

Language:

english

File:

PDF, 663 KB

english, 1987